2,3,4-Trihydroxybenzophenone Chemical Properties

Melting point:

139-141 °C (lit.)

Boiling point:

439.7±45.0 °C(Predicted)

Density 

1.413±0.06 g/cm3(Predicted)

vapor pressure 

0Pa at 20℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

ethanol: soluble2%, clear, yellow to very dark yellow-orange

form 

powder to crystal

pka

7.51±0.40(Predicted)

color 

Light yellow to Yellow to Orange

PH

6-7 (H2O)

Water Solubility 

13.22g/L(24.99 ºC)

BRN 

2697065

InChIKey

HTQNYBBTZSBWKL-UHFFFAOYSA-N

LogP

2.8 at 23℃

CAS DataBase Reference

1143-72-2(CAS DataBase Reference)

EPA Substance Registry System

Methanone, phenyl(2,3,4-trihydroxyphenyl)- (1143-72-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

1

TSCA 

Yes

HS Code 

29145090

MSDS

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2,3,4-Trihydroxybenzophenone Usage And Synthesis

Uses

2,3,4-Trihydroxybenzophenone is used in manufacturing method of electrophotographic photosensitive member containing styrene acrylic resin particle and melamine formaldehyde resin particle.

Definition

ChEBI: 2,3,4-trihydroxbenzophenone is a benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator. It has a role as a quorum sensing inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, a human urinary metabolite, a rat metabolite and a drug metabolite. It is a hydroxybenzophenone and a benzenetriol.

Preparation

Preparation by reaction of benzoic acid with pyrogallol,
in the presence of zinc chloride during 3 h at 145°;
in the presence of Amberlyst-15 (a strongly acid ion exchanger) in chlorobenzene during 10 h at 131–132° (60%);
in the presence of Amberlite IR-120 or Zeokarb 225 (cation exchange resins, sulfonic acid type) during 3 h at 160° (14%);
in the presence of boron trifluoride in ethyl ether at 0° (44%).

General Description

2,3,4-Trihydroxybenzophenone is a hydroxylated benzophenone UV filter and has been quantitated in sea water samples by dispersive liquid-liquid microextraction followed by GC-MS. Estrogenic activity of 2,3,4-trihydroxybenzophenone has been tested by yeast-two hybrid assay.

Flammability and Explosibility

Not classified

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