2-Bromopyrazine Chemical Properties

Boiling point:

61°C/10mmHg(lit.)

Density 

1.757 g/mL at 25 °C

refractive index 

n20/D1.580

Flash point:

92℃

storage temp. 

-20°C

pka

-1.15±0.10(Predicted)

form 

clear liquid

color 

Colorless to Light orange to Yellow

InChIKey

WGFCNCNTGOFBBF-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41-37/38

Safety Statements 

26-39

WGK Germany 

3

HS Code 

2933998090

2-Bromopyrazine Usage And Synthesis

Synthesis

A mixture of (2H)-pyrazinone (4.2 g, 0.044 mmol) and phosphorous oxybromide (25 g, 0.088 mole) was heated at 105 °C for 1.5 h. After cooling to room temperature, the mixture was poured on crushed ice (300 g) and made neutral with sodium hydrogen carbonate. The mixture was extracted with dichloromethane (2 x 100 mL). The extract was dried with magnesium sulfate and evaporated under vacuum. The residue was distilled under vacuum (70 °C, 12 torr). 2-Bromopyrazine (3.2 g, 46 %) was obtained as a colourless liquid[1].

References

[1] Laurence Decrane, Alain Turck, Nelly Plé. “Metalation of bromodiazines. Diazines XL.” Journal of Heterocyclic Chemistry 42 4 (2009): 509–513.

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