Isoderrone Chemical Properties

Boiling point:

562.1±50.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

cryst.

pka

6.49±0.20(Predicted)

color 

Yellow

Isoderrone Usage And Synthesis

Description

Isoderrone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 27 ± 7 uM, suggests that it may be a new drug for treatment of type 2 diabetes. Isoderrone shows inhibitory effects on α-glucosidase in vitro.

Definition

ChEBI: Isoderrone is a hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5 and 7 and a 6,6-dimethyl-3,6-dihydro-2H-pyran across positions 3' and 4' respectively. It has been isolated from Ficus mucuso. It has a role as a plant metabolite. It is functionally related to an isoflavone.

target

Tyrosinase

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