L-LEUCINE-2,3,3,4,5,5,5,6,6,6-D10 Chemical Properties

Melting point:

>300 °C(lit.)

storage temp. 

Refrigerator

solubility 

Aqueous Acid (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

optical activity

[α]25/D +14.5°, c = 2 in 5 M HCl

CAS Number Unlabeled

61-90-5

CAS Number Unlabeled

61-90-5

Safety Information

WGK Germany 

3

L-LEUCINE-2,3,3,4,5,5,5,6,6,6-D10 Usage And Synthesis

Uses

L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. DOI:10.1371/journal.pgen.1003857
[3] Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. DOI:10.1186/1743-7075-9-77
[4] Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. DOI:10.2337/db11-0765

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