D-alpha-Tocopheryl acetate Chemical Properties

Melting point:

~25 °C(lit.)

alpha 

3 º (c=2, in ethanol 25 ºC)

Boiling point:

224 °C0.3 mm Hg(lit.)

Density 

0.953 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.496(lit.)

Flash point:

>230 °F

storage temp. 

room temp

solubility 

Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils, soluble in ethanol (96 per cent).

form 

oil or semi-solid

color 

yellow

Odor

cryst., odorless

Water Solubility 

<0.1 g/100 mL at 17 ºC

Merck 

14,9495

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

12.260 (est)

CAS DataBase Reference

58-95-7(CAS DataBase Reference)

NIST Chemistry Reference

Vitamin e acetate(58-95-7)

EPA Substance Registry System

D-.alpha.-Tocopheryl acetate (58-95-7)

Safety Information

Safety Statements 

24/25

WGK Germany 

1

RTECS 

GP8280000

HS Code 

29362800

MSDS

• Language:English Provider:D-alpha-Tocopheryl acetate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

D-alpha-Tocopheryl acetate Usage And Synthesis

Description

D-alpha-tocopheryl acetate is a natural form of vitamin E and it is stable in terms of shelf life. It is probably the best form for people actively trying to prevent heart disease. It is used in the dietary and clinical supplementations.

References

[1] Jack Challem, User’s Guide to Nutritional Supplements, 2003
[2] M. K. Horwitt, Relative biological values of d-alpha-tocopheryl acetate and all-rac-alpha-tocopheryl acetate in man, The American Society for Clinical Nutrition, 1980, vol. 33, 1856-1860

Chemical Properties

off-white crystalline solid

Uses

Used in prevention and treatment of vitamin E deficiencies.

Uses

α-Tocopherol acetate is the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.

Uses

(+)-α-Tocopherol acetate has been used:

• as a component of growth medium for retinal cell lines
• as an external standard in high performance liquid chromatography (HPLC) to study its composition in leafy vegetables
• in the preparation of trans-resveratrol-encapsulated lipid nanocarriers (R-nano)

Definition

ChEBI: Alpha-Tocopherol acetate is a tocol.

General Description

Odorless off-white crystals. Darkens at 401° F.

Air & Water Reactions

D-alpha-Tocopheryl acetate may be sensitive to prolonged exposure to light and air. . Insoluble in water.

Reactivity Profile

An ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for D-alpha-Tocopheryl acetate are not available. D-alpha-Tocopheryl acetate is probably combustible.

Biochem/physiol Actions

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.

Contact allergens

Tocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

D-alpha-Tocopheryl acetate(58-95-7)Related Product Information

• Dihydromyrcenol
• Cellulose acetate
• Benzyl acetate
• 2-Butoxyethyl acetate
• Ethyl acetate
• Ethylene glycol monoethyl ether acetate
• Trenbolone acetate
• DL-ALPHA-TOCOPHEROL ACETATE
• Sodium acetate
• Retinyl acetate
• POLY(VINYL ACETATE)
• Glatiramer acetate
• Triacetin
• 1-Methoxy-2-propyl acetate
• Vinyl acetate
• Isopropyl acetate
• Amyl acetate
• Tocopheryl acetate