CAY10568 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 5 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.5 mg/ml

form 

A crystalline solid

CAY10568 Usage And Synthesis

Description

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported.¹ CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.

Uses

CAY10568 is a compound based on QX-314 (HY-101350). CAY10568 is physically smaller and less hydrophobic than the QX-314. CAY10568 can be used in studies of inflammation and pain perception[1].

References

1. Binshtok, A.M., Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers Nature 449,607-610(2007).

CAY10568(22913-17-3)Related Product Information

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• CAY10568
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• (4,6-Dimethyl-m-phenylenebis(iminocarbonylmethylene))bis(diethylmethyl ammonium iodide)
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