OPHIOPOGONIN D Chemical Properties

Melting point:

263-265 °C

Density 

1.40

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMF:30.0(Max Conc. mg/mL);35.09(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);35.09(Max Conc. mM)
Ethanol:15.0(Max Conc. mg/mL);17.54(Max Conc. mM)

form 

A solid

pka

13.01±0.70(Predicted)

color 

White to off-white

OPHIOPOGONIN D Usage And Synthesis

Uses

Ophiopogonin D is a natural product isolated from Radix Ophiopogon japonicus that protects the heart against doxorubicin-induced autophagic injury by reduction of both ROS generation and the disruption of the mitochondrial membrane damage.

Application

Ophiopogonin D is a bioactive compound that is found in Salvia miltiorrhiza. It has been shown to have hypoglycemic effects and significant cytotoxicity against tumor cells, which may be due to its ability to inhibit glucose uptake. It also causes mitochondrial membrane potential reduction, leading to the induction of apoptosis. This compound also has immunomodulatory effects. In addition, it inhibits the activation of toll-like receptors and prevents the translocation of nuclear factor-κB into the nucleus. Ophiopogonin D also has an effect on bowel disease, myocardial infarcts, and energy metabolism by inhibiting c-jun phosphorylation.

Definition

ChEBI: Ophiopogonin D is a steroid saponin.

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