(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Chemical Properties

Boiling point:

865.2±65.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Soluble to 50 mM in DMSO and to 100 mM in ethanol

form 

Powder

pka

12.79±0.20(Predicted)

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Usage And Synthesis

Uses

Somatostatin receptors are often overexpressed in tumours and are potential therapeutic targets. Somatostatin receptor agonists can be used to study signaling pathways related somatostatin receptor.N-?[(1R)?-?2-?[[[3-?(Aminomethyl)?cyclohexyl]?methyl]?amino]?-?1-?(1H-?indol-?3-?ylmethyl)?-?2-?oxoethyl]?-spiro[1H-?indene-?1,?4''-?piperidine]?-?1''-?carboxamide is a selective somatostatin sst2 receptor agonist.

Biological Activity

Potent and selective somatostatin sst 2 receptor agonist (K i values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst 2 , sst 1 , sst 4 , sst 3 and sst 5 receptors respectively).

storage

Store at +4°C

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264(208706-12-1)Related Product Information

• (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
• SPIRO[INDENE-1,4'-PIPERIDINE]
• 1,3-Cyclohexanebis(methylamine)