2,6-DICHLOROPYRIDINE-3,4-DIAMINE Chemical Properties

Melting point:

181-183℃

Boiling point:

424.0±40.0 °C(Predicted)

Density 

1.602±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.50±0.50(Predicted)

Appearance

light brown solid

InChI

InChI=1S/C5H5Cl2N3/c6-3-1-2(8)4(9)5(7)10-3/h1H,9H2,(H2,8,10)

InChIKey

HDNVWGXGFBVDKV-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=CC(N)=C1N

Safety Information

RIDADR 

UN2811

HS Code 

2933399990

2,6-DICHLOROPYRIDINE-3,4-DIAMINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2,6-dichloro-3,4-pyridinediamine from 4-amino-2,6-dichloro-3-nitropyridine was as follows: 2,6-dichloro-3-nitro-4-pyridinamine (881 mg, 4.24 mmol) was dissolved in ethanol (15 mL), followed by the addition of stannic chloride(II) (3212 mg, 16.94 mmol) in batches over a period of 5 minutes . The reaction mixture was stirred under nitrogen protection at 50°C for 3 h. Monitoring by LCMS showed about 60% conversion. After continuing the reaction for 3 h, LCMS analysis showed that the conversion was almost complete. The reaction solution was cooled to room temperature and extracted by partitioning with saturated aqueous sodium bicarbonate (50 mL) and ethyl acetate (50 mL). The organic layer was dried over hydrophobic glass material, concentrated and dried under vacuum overnight to afford the target compound 2,6-dichloro-3,4-pyridinediamine as a yellow solid (734 mg).LCMS (Method B) analysis showed retention time (Rt) = 0.57 min and molecular ion peak (MH+) = 178.

References

[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 1, p. 42 - 46
[2] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 67
[3] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144
[4] Patent: WO2012/167733, 2012, A1. Location in patent: Page/Page column 35
[5] Patent: WO2012/167423, 2012, A1. Location in patent: Page/Page column 32

2,6-DICHLOROPYRIDINE-3,4-DIAMINE(101079-63-4)Related Product Information

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