PYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties

Melting point:

105 °C

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

0.33±0.30(Predicted)

Appearance

White to off-white Solid

Safety Information

Risk Statements 

20/21/22

Safety Statements 

36/37

HS Code 

29335990

PYRAZOLO[1,5-A]PYRIMIDINE Usage And Synthesis

Chemical Properties

Light yellow solid

Uses

Pyrazolo[1,5-a]pyrimidine is being researched as a protein kinase CK2 inhibitors.

Synthesis

Preparation of compound 23a: 1H-pyrazol-3-ylamine (32 g, 0.386 mol) and (E)-3-dimethylaminoacrylaldehyde (38.2 g, 0.386 mol) were dissolved in ethanol (500 mL), and the reaction was carried out at reflux for 6 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 2:1) to afford the target product, pyrazolo[1,5-a]pyrimidine 23a, as a white solid (30 g, 65% yield).

References

[1] Synthesis, 2006, # 1, p. 59 - 62
[2] Patent: WO2010/16005, 2010, A1. Location in patent: Page/Page column 116

PYRAZOLO[1,5-A]PYRIMIDINE(274-71-5)Related Product Information

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• Pyrazolo[1,5-a]pyridine
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• Pyrazolam
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• 4,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDINE-3-CARBOXYLIC ACID
• PYRAZOPHOS
• 1-[2-(4-CHLOROPHENYL)-7-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-6-YL]ETHAN-1-ONE
• 6-(TERT-BUTYLSULFONYL)-2-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE
• 7-Aminopyrazolo[1,5-a]pyrimidine-6-carbonitrile
• ETHYL 7-METHYL-2-(2-THIENYL)PYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE
• 7-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE
• ETHYL 7-METHYL-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE