2,4-DICHLORO-7-BROMOQUINAZOLINE Chemical Properties

Boiling point:

330.2±24.0 °C(Predicted)

Density 

1.851±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1.17±0.30(Predicted)

Appearance

White to yellow Solid

Safety Information

HS Code 

2933599590

2,4-DICHLORO-7-BROMOQUINAZOLINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2,4-dichloro-7-bromoquinazoline from 7-bromoquinazoline-2,4(1H,3H)-dione was as follows: 205.0 g (0.84 mol) of 7-bromo-1H-benzo[d]-1,3-oxazine-2,4-dione was suspended in 1.26 L (12.59 mol) of phosphorochloride at room temperature, followed by the addition of 71.34 mL (0.42 mol) N-ethyl diisopropylamine. The reaction mixture was heated to reflux and kept for 36 hours. Upon completion of the reaction, 193.6 g of the target product 7-bromo-2,4-dichloroquinazoline was obtained by a conventional post-processing step. The product was analyzed by HPLC/MS and showed that the (M+H)+ peak was located at 277/279, confirming the solid form.

References

[1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0174
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 21, p. 4904 - 4907
[3] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 92-93
[4] Patent: US2014/38952, 2014, A1. Location in patent: Page/Page column 0160-0161
[5] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 6,

2,4-DICHLORO-7-BROMOQUINAZOLINE(959237-68-4)Related Product Information

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