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3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester

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3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Basic information

Product Name:
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
Synonyms:
  • Ulmus pumila saponin I
  • 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
  • Kudinoside H
  • Zigu-glucoside I
  • Gouguside 7
  • Ziyu-glycoside Ⅰ
  • Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-
  • [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
CAS:
35286-58-9
MF:
C41H66O13
MW:
766.95
EINECS:
233-305-4
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
35286-58-9.mol
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3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Chemical Properties

Melting point:
198-202 ºC
Boiling point:
841.9±65.0 °C(Predicted)
Density 
1.35
storage temp. 
-20°C, protect from light
solubility 
Soluble in acetonitrile and methanol;
form 
powder
pka
12.52±0.70(Predicted)
color 
White
Water Solubility 
insoluble in water
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3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Usage And Synthesis

Chemical Properties

White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Burnet.

Uses

Used for content determination/identification/pharmacological experiments, etc.

Biological Activity

Ziyuglycoside I, isolated from the roots of S. officinalis, has anti-wrinkle activity and increases collagen type I expression. It can be used as an active ingredient in cosmetics and induces p53-mediated cell cycle arrest and apoptosis (apoptosis), which can be used in the study of triple-negative breast cancer.

Physiological effects

Ziyuglycoside I has the functions of vasoconstriction, hemostasis and antifungal.

in vitro

Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I ( 5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas- 8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.

Cell Viability Assay

Cell Line: MDA-MB-231 cells < /td>
Concentration: 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity on MDA-MB-231 cells.

Cell Cycle Analysis

Cell Line: MDA-MB-231 cells
Concentration: 5 μM, 10 μM, and 20 μM
Incubation Time: 24 hours
Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells

Western Blot Analysis

Cell Line: MDA-MB-231 cells
Concentration: 5 μM, 10 μM, and 20 μM
Incubation Time: 24 hours
Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.

3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl esterSupplier

Chembest Research Laboratories Limited
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BioBioPha Co., Ltd.
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ShangHai YuanYe Biotechnology Co., Ltd.
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shyysw007@163.com
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3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester(35286-58-9)Related Product Information