3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Chemical Properties

Melting point:

241-242℃

Boiling point:

257℃

Density 

1.19

Flash point:

120℃

storage temp. 

Sealed in dry,Room Temperature

pka

12?+-.0.20(Predicted)

3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3,4-dihydro-1H-quinazolin-2-one from 2-aminobenzylamine and molybdenum hexacarbonyl was as follows: the reaction was carried out in a two-chamber system. First, 2-aminobenzylamine, Pd(OAc)2 (0.05 eq.) and Cu(OAc)2 (0.5 eq.) were added to the reaction chamber and dissolved in 1,4-dioxane (2 mL). In a CO chamber, Mo(CO)6 (200 mg) was dissolved in 1,4-dioxane (2 mL). Subsequently, 1,8-diazabicyclo[5.4.0]undec-7-ene was added to the system. The two-compartment system was placed in a Dry-Syn heating block and heated to 95°C for the reaction. Upon completion of the reaction, the reaction mixture was filtered through a short silica gel plug and subsequently purified by fast column chromatography.

References

[1] Molecules, 2017, vol. 22, # 10,

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