Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antibiotics >  Other antibiotic Drugs >  Cinchonidine

Cinchonidine

Basic information Safety Supplier Related

Cinchonidine Basic information

Product Name:
Cinchonidine
Synonyms:
  • (8-alpha,9r)-cinchonan-9-o
  • (8alpha,9theta)-cinchonan-9-o
  • (8s,9r)-cinchonidine
  • 2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-
  • Cinchonan-9-ol
  • Cinchonan-9-ol, (8alpha,9R)-
  • Cinchovatine
  • Cinchonidinederivedcatalyst
CAS:
485-71-2
MF:
C19H22N2O
MW:
294.39
EINECS:
207-622-3
Product Categories:
  • AMEBARSONE
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Alkaloids
  • chiral
  • Biochemistry
  • for Resolution of Acids
  • Optical Resolution
  • Quinoline Alkaloids
  • Quinolinecarboxylic Acids, etc.
  • Quinolines
  • cyclic compounds
  • Synthetic Organic Chemistry
Mol File:
485-71-2.mol
More
Less

Cinchonidine Chemical Properties

Melting point:
204-206 °C(lit.)
alpha 
-115 º (c=1, EtOH)
Boiling point:
436.16°C (rough estimate)
Density 
1.0863 (rough estimate)
refractive index 
-107.5 ° (C=1, EtOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
0.25g/l
pka
5.80, 10.03(at 25℃)
form 
Crystalline Powder
color 
White to cream
PH
9 (0.2g/l, H2O, 20℃)
optical activity
[α]23/D 109.2°, c = 1.5 in ethanol
Water Solubility 
Insoluble
Sensitive 
Light Sensitive
Merck 
14,2286
BRN 
89690
Stability:
Stable, but light-sensitive. Incompatible with strong oxidizing agents.
InChIKey
KMPWYEUPVWOPIM-NAHPKXJFSA-N
CAS DataBase Reference
485-71-2(CAS DataBase Reference)
NIST Chemistry Reference
Cinchonidine(485-71-2)
EPA Substance Registry System
Cinchonan-9-ol, (8.alpha.,9R)- (485-71-2)
More
Less

Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-42/43-36/37/38-20/22-48/22-43-22-63
Safety Statements 
22-24/25-36/37-36-26
RIDADR 
1544
WGK Germany 
3
RTECS 
GD2975000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29392900
Toxicity
LD50 i.p. in rats: 206 mg/kg (Johnson, Poe); LD50 orally in quail: >316 mg/kg (Schafer)

MSDS

More
Less

Cinchonidine Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

antiamebic, antiprotozoal

Uses

Occurs in most varieties of Cinchona

Definition

ChEBI: 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Purification Methods

Crystallise cinchonidine from aqueous EtOH. For the N-benzylcinchonidinium chloride see above entry in this section. [Beilstein 23 III/IV 2824.]

CinchonidineSupplier

Maya High Purity Chemicals Gold
Tel
+86 (573) 82222445 (0)18006601000 QQ:452520369
Email
sales@maya-r.com
Shanghai Uteam Biotechnology Co., Ltd. Gold
Tel
021-65211385-102
Email
3338195766@QQ.com;
Shanghai Biological Technology Development Co., Ltd. Gold
Tel
021-65211385-102
Email
lj80414@hotmail.com;
Porton Fine Chemicals Gold
Tel
023-86083200-6830
Email
yan.shangguan@porton.cn;
Shanghai GAOXIANG Chemical Co., Ltd. Gold
Tel
021-57816257-
Email
fecpo@139.com