Cinchonidine
Cinchonidine Basic information
- Product Name:
- Cinchonidine
- Synonyms:
-
- (8-alpha,9r)-cinchonan-9-o
- (8alpha,9theta)-cinchonan-9-o
- (8s,9r)-cinchonidine
- 2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-
- Cinchonan-9-ol
- Cinchonan-9-ol, (8alpha,9R)-
- Cinchovatine
- Cinchonidinederivedcatalyst
- CAS:
- 485-71-2
- MF:
- C19H22N2O
- MW:
- 294.39
- EINECS:
- 207-622-3
- Product Categories:
-
- AMEBARSONE
- Aromatics
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Alkaloids
- chiral
- Biochemistry
- for Resolution of Acids
- Optical Resolution
- Quinoline Alkaloids
- Quinolinecarboxylic Acids, etc.
- Quinolines
- cyclic compounds
- Synthetic Organic Chemistry
- Mol File:
- 485-71-2.mol
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Cinchonidine Chemical Properties
- Melting point:
- 204-206 °C(lit.)
- alpha
- -115 º (c=1, EtOH)
- Boiling point:
- 436.16°C (rough estimate)
- Density
- 1.0863 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- -107.5 ° (C=1, EtOH)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 0.25g/l
- form
- Crystalline Powder
- pka
- 5.80, 10.03(at 25℃)
- color
- White to cream
- PH
- 9 (0.2g/l, H2O, 20℃)
- optical activity
- [α]23/D 109.2°, c = 1.5 in ethanol
- Water Solubility
- Insoluble
- Sensitive
- Light Sensitive
- Merck
- 14,2286
- BRN
- 89690
- Stability:
- Stable, but light-sensitive. Incompatible with strong oxidizing agents.
- InChIKey
- KMPWYEUPVWOPIM-NAHPKXJFSA-N
- LogP
- 2.68 at 25℃
- CAS DataBase Reference
- 485-71-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Cinchonidine(485-71-2)
- EPA Substance Registry System
- Cinchonan-9-ol, (8.alpha.,9R)- (485-71-2)
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Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-42/43-36/37/38-20/22-48/22-43-22-63
- Safety Statements
- 22-24/25-36/37-36-26
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- GD2975000
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29392900
- Toxicity
- LD50 i.p. in rats: 206 mg/kg (Johnson, Poe); LD50 orally in quail: >316 mg/kg (Schafer)
MSDS
- Language:English Provider:L-Cinchonidine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
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Cinchonidine Usage And Synthesis
Chemical Properties
white to light yellow crystal powde
Uses
antiamebic, antiprotozoal
Uses
Cinchonidine occurs in most varieties of Cinchona bark and is stereoisomeric with Cinchonine. Cinchonidine exhibits Antimalarial properties.
Definition
ChEBI: 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.
Flammability and Explosibility
Non flammable
Purification Methods
Crystallise cinchonidine from aqueous EtOH. For the N-benzylcinchonidinium chloride see above entry in this section. [Beilstein 23 III/IV 2824.]
Cinchonidine Preparation Products And Raw materials
Preparation Products
(S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE(R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE(S)-1,1'-SPIROBIINDANE-7,7'-DIOL(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-PHENOXY(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE1,1'-SPIROBIINDANE-7,7'-DIOL1,1'-Bis (di-t-butylphosphino)ferrocene palladium dichloride, 1,1'-BIS(DI-TERT-BUTYLPHOSPHINO)FERROCENE2-(Dicyclohexylphosphino)biphenylEsfenvalerateQUININE SULFATEFosinoprilBenazeprilN-Benzylcinchonidinium chloride
CinchonidineSupplier
Shanghai Uteam Biotechnology Co., Ltd. Gold
- Tel
- 021-36031160 13311776681
- 3338195766@QQ.com
Shanghai Biological Technology Development Co., Ltd. Gold
- Tel
- 021-69955236-807 13918189704
- chinaruji@chinaruji.com
Shanghai Qiao Chemical Science Co., Ltd Gold
- Tel
- 021-58892003
- info@qiaochem.com
xi'an renyang Biotechnology Co., Ltd. Gold
- Tel
- 13299086402
- renyangbiotech@163.com
Shanxi Yuning Biotechnology Co., Ltd. Gold
- Tel
- 13623677056
- 1639455302@qq.com
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Cinchonidine(485-71-2)Related Product Information
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- 3-Methoxybenzaldehyde
- p-Anisidine
- Quinidine
- VINYL PROPIONATE
- 4-Methoxybenzylchloride
- Cinchonine
- Triethoxyvinylsilane
- Methanol
- DL-CARNITINE
- N-Vinyl-2-pyrrolidone
- Vinylmagnesium bromide
- p-Anisaldehyde
- (Trifluoromethoxy)benzene