1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Chemical Properties

Boiling point:

55-57 °C11 mm Hg(lit.)

Density 

0.794 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.422(lit.)

Flash point:

125 °F

storage temp. 

2-8°C

form 

clear liquid

color 

Colorless to Almost colorless

BRN 

2076559

CAS DataBase Reference

14542-93-9(CAS DataBase Reference)

EPA Substance Registry System

Pentane, 2-isocyano-2,4,4-trimethyl- (14542-93-9)

Safety Information

Hazard Codes 

Xn

Risk Statements 

10-20/21/22

Safety Statements 

23-36/37

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

10-21

HS Code 

2929 90 00

HazardClass 

3.2

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

1,1,3,3-Tetramethylbutyl isocyanide was used in the synthesis of substituted furans and imides.

Preparation

To a stirred solution of 83.0 g (0.528 mole) of N-(l,l,3,3-tetramethylbutyl) formamide in 11 of DMF was added dropwise, under a nitrogen atmosphere, a solution made up of thionyl chloride (40.3 ml, 0.55 mole) dissolved in 150 ml of DMF. The addition was at such a rate that the temperature did not exceed -50°C. After the addition, the cooling bath was removed momentarily to allow the temperature to increase to -35°C and then it was replaced while 118.0 g (1.11 mole) of sodium carbonate (anhydrous grade) was added. Then the cooling bath was removed and the reaction mixture was diluted with ice-cold water in a separatory funnel and then extracted with pentane. The pentane extract was dried over sodium sulfate and concentrated, and the product distilled to yield 68.4 g (93% yield), b.p. 55.5-56.6°C (11 mm). Infrared spectrum (neat) 2110 c m " 1 (s); nmr (neat) 51.08 [s, 9, C(CH3) 2] , 1.43 [t, 6, J = 2Hz, C(CH3) 2] , 1.58 (t, 2, J = 2.3 Hz, CH2).

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE(14542-93-9)Related Product Information

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