2-Hydroxy Atorvastatin Lactone-d5 Chemical Properties

Melting point:

103-107°C

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow to Beige

Stability:

Hygroscopic

2-Hydroxy Atorvastatin Lactone-d5 Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790. DOI:10.3109/00498254.2012.661100
[3] Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. DOI:10.1097/FJC.0b013e318123767f

2-Hydroxy Atorvastatin Lactone-d5(265989-50-2)Related Product Information

• Ortho-Hydroxy atorvastatin calcium salt
• di(2-Hydroxy Atorvastatin) CalciuM Salt
• O-HYDROXY ATORVASTATIN LACTONE
• Atorvastatin Isopropyl Ester
• ATV-FX1 sodiuM salt
• Dihydroxy Diketo Atorvastatin IMpurity
• 5-Oxo Atorvastatin tert-Butyl Ester
• Atorvastatin Impurity 46
• Atorvastatin Impurity 38
• Atorvastatin
• 3-Oxo Atorvastatin tert-Butyl Ester
• Atorvastatin Impurity 31
• Atorvastatin Impurity 15
• Difluoro Atorvastatin Acetonide tert-Butyl Ester
• 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
• 2,3-Dehydroxy Atorvastatin Sodium Salt
• Atorvastatin Dehydro Lactone
• Atorvastatin Impurity 20