6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Chemical Properties

Melting point:

170-172℃

Boiling point:

376.3±42.0 °C(Predicted)

Density 

1.559±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

13.92±0.20(Predicted)

form 

Powder

color 

Brown

Sensitive 

Light Sensitive

InChI

InChI=1S/C9H8BrNO/c10-7-2-3-8-6(5-7)1-4-9(12)11-8/h2-3,5H,1,4H2,(H,11,12)

InChIKey

MQWZSSIUHXNNTM-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(Br)C=C2)CCC1=O

CAS DataBase Reference

3279-90-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-52-22

Safety Statements 

26-36/37/39

HS Code 

2933499090

6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Usage And Synthesis

Synthesis

3,4-Dihydroquinolin-2(1H)-one (2.73 g, 18.55 mmol) was dissolved in N,N-dimethylacetamide (30 mL) and N,N-dimethylacetamide (10 mL) solution of N-bromosuccinimide (3.30 g, 18.55 mmol) was added slowly and dropwise in an ice water bath. The reaction solution continued to react in an ice water bath with stirring for 6 hours and then warmed up to room temperature for 12 hours. At the end of the reaction, water (50 mL) was added to the reaction mixture and extracted with ethyl acetate (50 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate (v/v) = 3/1) to afford the title compound as a white solid (3.86 g, 92.1%).

6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(3279-90-1)Related Product Information

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