2-ACETYLCYCLOHEXANONE Chemical Properties

Melting point:

-11°C

Boiling point:

111-112 °C/18 mmHg (lit.)

Density 

1.078 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.509(lit.)

Flash point:

175 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Chloroform, Ethyl Acetate

form 

Liquid

pka

10.91±0.20(Predicted)

color 

Clear colorless to light yellow

Water Solubility 

Not miscible in water.

BRN 

1858621

InChIKey

OEKATORRSPXJHE-UHFFFAOYSA-N

CAS DataBase Reference

874-23-7(CAS DataBase Reference)

EPA Substance Registry System

Cyclohexanone, 2-acetyl- (874-23-7)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29142990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-ACETYLCYCLOHEXANONE Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

2-Acetylcyclohexanone was used in the synthesis of anilinoethanolamines.

Uses

2-Acetylcyclohexanone is used in the synthesis of 1-(pyridyl)ethanol derivatives that can reduce keto-esters and ketones. Also used in the synthesis of phenothiazine derivatives that can inhibit prote in farnesyltransferase molecules and some that show anti-proliferative activity.

General Description

The keto-enol tautomerism of 2-acetylcyclohexanone (ACHE) in water was studied.

Purification Methods

Dissolve it in ligroin (b 30-60o), wash it with saturated aqueous NaHCO3, dry over Drierite and fractionate in a vacuum. [Perfetti & Levine J Am Chem Soc 75 626 1953, Manyik et al. J Am Chem Soc 75 5030 1953, Eistert & Reiss Chem Ber 87 108 1954.] It forms a Cu salt which crystallises in green leaflets from EtOH, m 162-163o [UV: McEntee & Pinder J Chem Soc 4419 1957].

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