2,5-Diazaspiro[3.4]octane-5-carboxylicacid-1,1-dimethylethylester Chemical Properties

storage temp. 

2-8°C

form 

solid

Appearance

Colorless to light yellow Solid-Liquid Mixture

InChI

1S/C11H20N2O2/c1-10(2,3)15-9(14)13-6-4-5-11(13)7-12-8-11/h12H,4-8H2,1-3H3

InChIKey

XKASCTCECDLMSI-UHFFFAOYSA-N

SMILES

CC(C)(C)OC(=O)N1CCCC12CNC2

Safety Information

WGK Germany 

WGK 3

HS Code 

2933998090

Storage Class

11 - Combustible Solids

2,5-Diazaspiro[3.4]octane-5-carboxylicacid-1,1-dimethylethylester Usage And Synthesis

Synthesis

2,5-Diazaspiro[3.4]octane-5-carboxylicacid-1,1-dimethylethylester is a heterocyclic organic compound frequently used as a pharmaceutical intermediate. A few examples of 2,5-diazaspiro[3.4]octanes with N-Boc-protected azetidine nitrogen were obtained by condensation of N-Boc-azetidine-3-one with N-benzylbut-3-yn-1-amine elaborated for a streamlined synthesis of C(sp3)-rich N-heterospirocycles via visible-light-mediated Ir-photocatalyzed reactions^[1].

References

[1] Flodén, N.J.; Trowbridge, A.; Willcox, D.; Walton, S.M.; Kim, Y.; Gaunt, M.J. Streamlined Synthesis of C-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis. J. Am. Chem. Soc. 2019, 141, 8426–8430. DOI:10.1021/jacs.9b03372