VX-222 Chemical Properties

Boiling point:

640.5±55.0 °C(Predicted)

Density 

1.21

storage temp. 

Store at -20°C

solubility 

≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH

form 

solid

pka

3.67±0.10(Predicted)

VX-222 Usage And Synthesis

Description

Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; K_i = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC₅₀ = 5 nM).

Uses

VX-222, s a novel, potent and selective inhibitor of HCV polymerase .

Definition

ChEBI: 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-[(4-methylcyclohexyl)-oxomethyl]amino]-2-thiophenecarboxylic acid is a thiophenecarboxylic acid.

target

HCV RNA-dependent RNA polymerase

References

[1] GUANGHUI YI. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.[J]. Antimicrobial Agents and Chemotherapy, 2012, 56 2: 830-837. DOI: 10.1128/aac.05438-11

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