ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Proteases > HCV Protease Inhibitors > VX-222
VX-222
VX-222 Basic information
- Product Name:
- VX-222
- Synonyms:
-
- VX-222
- 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid
- VCH 222
- VCH222
- VCH-222
- VX-222, VCH222
- VX-222 (VCH-222, LoMibuvir)
- 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-
- CAS:
- 1026785-59-0
- MF:
- C25H35NO4S
- MW:
- 445.61
- Product Categories:
-
- Inhibitors
- Inhibitor
- Mol File:
- 1026785-59-0.mol
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VX-222 Chemical Properties
- Boiling point:
- 640.5±55.0 °C(Predicted)
- Density
- 1.21
- storage temp.
- Store at -20°C
- solubility
- ≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH
- form
- solid
- pka
- 3.67±0.10(Predicted)
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VX-222 Usage And Synthesis
Description
Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).
Uses
VX-222, s a novel, potent and selective inhibitor of HCV polymerase .
Definition
ChEBI: 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-[(4-methylcyclohexyl)-oxomethyl]amino]-2-thiophenecarboxylic acid is a thiophenecarboxylic acid.
target
HCV RNA-dependent RNA polymerase
VX-222Supplier
JinYan Chemicals(ShangHai) Co.,Ltd.
- Tel
- 13817811078
- sales@jingyan-chemical.com
Jinan Trio PharmaTech Co., Ltd.
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Shanghai civi chemical technology co.,Ltd
- Tel
- 86-21-34053660
- sale@labgogo.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com