2-oxa-6-azaspiro[3.4]octane Chemical Properties

Boiling point:

187℃

Density 

1.08

Flash point:

63°(145°F)

storage temp. 

2-8°C(protect from light)

pka

10.55±0.20(Predicted)

Water Solubility 

Soluble in water.

InChI

InChI=1S/C6H11NO/c1-2-7-3-6(1)4-8-5-6/h7H,1-5H2

InChIKey

ZHAIMJRKJKQNQI-UHFFFAOYSA-N

SMILES

C1C2(CCNC2)CO1

Safety Information

HS Code 

29339900

2-oxa-6-azaspiro[3.4]octane Usage And Synthesis

Uses

2-Oxa-6-azaspiro[3.4]octane is involved in the preparation of azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives, which exhibits epidermal growth factor receptor (EGFR) inhibitory activities.

Application

2-Oxa-6-Azaspiro[3.4]Octane Hydrochloride may be useful in the preparation of aminocyanopyridine derivatives for the prevention or treatment of cancer or inflammatory diseases.

Synthesis

Tert-butyl 2-oxa-6-azaspiro[3.4]octane-6-carboxylate (86mg, 0.4mmol) was dissolved in dichloromethane (1mL), trifluoroacetic acid (2mL) was added to the system at room temperature, and the reaction solution was heated at 60°C for 2h. The reaction solution was cooled to room temperature and concentrated under reduced pressure to obtain crude product 2-oxa-6-azaspiro[3.4]octane.

2-oxa-6-azaspiro[3.4]octane(220290-68-6)Related Product Information

• 2-Oxa-6-azaspiro[3.4]octan-7-one
• 2-oxa-6-azaspiro[3,4]octane-6-carboxylic acid tert-butyl ester
• 1-Oxa-6-azaspiro[3.3]heptane oxalate