Amodiaquine-d10 Chemical Properties

Melting point:

194-198°C

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow to Light Yellow

Amodiaquine-d10 Usage And Synthesis

Description

Amodiaquine-d₁₀ is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine . It is active against several strains of P. falciparum in vitro (EC₅₀s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.

Chemical Properties

Pale Yellow Solid

Uses

An antimalarial.

IC 50

Plasmodium

References

[1] S T MARIGA. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.[J]. Antimicrobial Agents and Chemotherapy, 2004, 48 11: 4089-4096. DOI: 10.1128/aac.48.11.4089-4096.2004
[2] JULIANA M Sá T E W Jason L Chong. Malaria drug resistance: new observations and developments.[J]. Essays in biochemistry, 2011, 51: 137-160. DOI: 10.1042/bse0510137
[3] R. JACOBS W C D Alling. AN EVALUATION OF ANTIMALARIAL COMBINATIONS AGAINST PLASMODIUM BERGHEI IN THE MOUSE.[J]. Kisaengch’unghak chapchi. The Korean journal of parasitology, 1963, 11 1: 920-925. DOI: 10.2307/3275719

Amodiaquine-d10(1189449-70-4)Related Product Information

• AModiaquine IMpurity B
• 7-Chloro-4-(4-hydroxyanilino)quinoline
• N-(3-(DIETHYLAMINO)METHYL)-4-HYDROXYPHENYLACETAMIDE
• 4,7-Dichloroquinoline
• AModiaquine IMpurity A
• N-Desethyl AModiaquine Dihydrochloride
• N-Desethylamodiaquine-D5 dihydrochloride