MK-3903
MK-3903 Basic information
- Product Name:
- MK-3903
- Synonyms:
-
- MK-3903
- MK-3903; MK 3903; MK3903;1219737-12-8
- Benzoic acid, 5-[(5-[1,1'-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-
- AMPK,MK3903,AMP-activated protein kinase,inhibit,Inhibitor,MK-3903
- 5-((6-([1,1'-Biphenyl]-4-yl)-5-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid
- MK-3903, 10 mM in DMSO
- CAS:
- 1219737-12-8
- MF:
- C27H19ClN2O3
- MW:
- 454.9
- Product Categories:
-
- API
- Mol File:
- 1219737-12-8.mol
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MK-3903 Chemical Properties
- Boiling point:
- 712.6±70.0 °C(Predicted)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);219.83(Max Conc. mM)
- form
- A solid
- pka
- 3.40±0.25(Predicted)
- color
- White to off-white
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MK-3903 Usage And Synthesis
Uses
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
in vivo
The pharmacokinetics of MK-3903 (compound 42) in C57BL/6 mice, Sprague to Dawley rats, and beagle dogs are characterized by moderate systemic plasma clearance (5.0 to13 mL/min/kg), a volume of distribution at steady state of 0.6 to 1.1 L/kg, and a terminal halflife of ~2h. Acute oral administration of MK-3903 (3, 10, and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses[1].
IC 50
AMPK: 8 nM (EC50)
MK-3903Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
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- 17754423994 17754423994
- 2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
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- 21-31433387 15618786686
- sales@rechemscience.com