SB 743921 Chemical Properties

storage temp. 

-20°C

solubility 

H2O: soluble5mg/mL, clear

form 

powder

color 

white to beige

InChIKey

MLMZVWABFOLFGV-LNLSOMNWSA-N

Safety Information

WGK Germany 

3

SB 743921 Usage And Synthesis

Uses

SB 743921 Hydrochloride is a mitotic kinesin inhibitor, which can be used to treat lung disease in combination with other therapy.

Biological Activity

sb743921 is an inhibitor of kinesin spindle protein (ksp) with ki value of 0.1nm [1].as an inhibitor of mitotic kinesin ksp, sb743921 causes cell cycle arrest in mitosis, results in cell death. sb743921 is developed to treat for cancers. sb743921 is a potent and selective inhibitor. in the affinity assays, sb743921 shows ki values of 0.1nm and 0.12nm for human ksp and mouse ksp, respectively. it has no affinity with other kinesins. in the cellular assay, sb743921 exerts anti-proliferation efficacy in skov3, colo205, mv522 and mx1 with ic50 values of 0.02nm, 0.07nm, 1.7nm and 0.06nm. moreover, sb743921 is shown to have activity against human tumor xenografts colo205, mcf-7, sk-mes, h69, ovcar-3, ht-29, mda-mb-231 and a2780. sb743921 is also effective against p388 lymphocytic leukemia xenografts in mice [1].

References

[1] jackson j r, gilmartin a, dhanak d, et al. a second generation ksp inhibitor, sb-743921, is a highly potent and active therapeutic in preclinical models of cancer. proceedings of the american association for cancer research, 2006, 2006(2): b11.

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