9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Chemical Properties

Boiling point:

621.0±65.0 °C(Predicted)

Density 

1.279

storage temp. 

Store at +4°C

solubility 

Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)

form 

solid

pka

8.29±0.10(Predicted)

color 

Off-white

Stability:

Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Usage And Synthesis

Description

AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2

Uses

AZ 3146 is a protein kinase Mps1 inhibitor.

storage

Store at +4°C

References

1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309

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