9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one CAS#: 1124329-14-1

ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Cytoskeletal Signaling > Kinesin Inhibitors > 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Basic information Safety Supplier Related

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Basic information

Product Name:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Synonyms:

AZ 3146; AZ-3146
CS-511
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
AZ 3146
9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one
9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one
9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146
9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9

CAS:

1124329-14-1

MF:

C24H32N6O3

MW:

452.55

Product Categories:

Inhibitors

Mol File:

1124329-14-1.mol

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Chemical Properties

Boiling point:: 621.0±65.0 °C(Predicted)
Density: 1.279
storage temp.: Store at +4°C
solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form: solid
pka: 8.29±0.10(Predicted)
color: Off-white
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Usage And Synthesis

Description

AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2

Uses

AZ 3146 is a protein kinase Mps1 inhibitor.

IC 50

Mps1^Cat: 35 nM (IC₅₀)

storage

Store at +4°C

References

[1] LAURA HEWITT. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.[J]. Journal of Cell Biology, 2010, 190 1: 25-34. DOI:10.1083/jcb.201002133
[2] XING LIU. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells.[J]. Oncotarget, 2015: 34309-34320. DOI:10.18632/oncotarget.5295

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-oneSupplier

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