N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Chemical Properties

Melting point:

159.7-160.2 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))

Boiling point:

689.3±65.0 °C(Predicted)

Density 

1.447±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: >5mg/mL

form 

powder

pka

8.97±0.50(Predicted)

color 

yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Usage And Synthesis

Uses

VU 0255035 is a novel, selective antagonist of M1 mAChRs, which has potential treatment in CNS disorders.

Definition

ChEBI: N-[3-oxo-3-(4-pyridin-4-yl-1-piperazinyl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide is a member of pyridines and a member of piperazines.

Biological Activity

VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases). There are no highly selective M1 muscarinic receptor antagonists. The existing non-selective drugs do not permit direct evaluation of the role of M1 receptors in CNS fucntions and do not premit therapeutic targeting of M1 receptors in various disease states in which M1 receptors are implicated (epilepsy, Parkinsonμs disease, attention and cognitive disorders, dystonia, etc).

storage

Store at -20°C

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide(1135243-19-4)Related Product Information

• VU 0364770
• N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• VU 0365114
• VU 0357017 hydrochloride
• VU 0463841
• [Hexahydro-5-(4-pyridinyl)pyrrolo[3,4-c]pyrrol-2(1H)-yl][1-(5-isoquinolinylsulfonyl)-3-azetidinyl]-Methanone
• N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
• VU0453595
• VU 0364439
• 5-[1-(2-ethoxyphenyl)sulfonylazetidin-3-yl]-3-thiophen-3-yl-1,2,4-oxadiazole
• VU 0360223
• 2(5H)-Furanone, 3-(3-fluorophenyl)-4-(4-methoxyphenyl)-
• VU 0360172
• cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide
• Urea, N-(3,4-difluorophenyl)-N'-[3-methyl-1-(phenylmethyl)-1H-pyrazol-5-yl]-
• VU-0486321
• VU0238441