5alpha-Hydroxycostic acid
5alpha-Hydroxycostic acid Basic information
- Product Name:
- 5alpha-Hydroxycostic acid
- Synonyms:
-
- (2R,4aR,8aR)-Decahydro-8a-hydroxy-4a-methyl-alpha,8-bis(methylene)-2-naphthaleneacetic acid
- 5alpha-Hydroxycostic acid
- 5α-Hydroxycostic acid
- 2-Naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-α,8-bis(methylene)-, (2R,4aR,8aR)-
- 5α-Hydroxycosticacid
- CAS:
- 132185-83-2
- MF:
- C15H22O3
- MW:
- 250.33338
- Mol File:
- 132185-83-2.mol
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5alpha-Hydroxycostic acid Chemical Properties
- Boiling point:
- 406.4±38.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.42±0.11(Predicted)
- color
- White to off-white
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5alpha-Hydroxycostic acid Usage And Synthesis
Uses
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1].
target
VEGF | Src | AKT | NOS | FAK | PLCγ | ERK
References
[1] Liang N, et, al. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017 Jul;51(1):213-222. DOI:10.3892/ijo.2017.4004
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