Chonglou Saponin VII
Chonglou Saponin VII Basic information
- Product Name:
- Chonglou Saponin VII
- Synonyms:
-
- Chonglou Saponin VII
- Paris VII
- Chonglouoside Ⅶ
- Paris saponin VII
- Dioscinin
- Chonglou saponin Ⅶ
- β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-
- Polyphyllin VIT
- CAS:
- 68124-04-9
- MF:
- C51H82O21
- MW:
- 1031.2
- Mol File:
- 68124-04-9.mol
Chonglou Saponin VII Chemical Properties
- Melting point:
- 243-245 °C (decomp)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- Soluble in methanol;
- pka
- 12?+-.0.70(Predicted)
- form
- powder
- color
- White
- Water Solubility
- sparingly soluble in water
Chonglou Saponin VII Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Uses
Used for content determination/identification/pharmacological experiments, etc.
Biological Activity
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.
Pharmacology
Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.
in vitro
Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.
in vivo
Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.
target
| Akt
| p38
| Bcl-2
| Caspase-9
| Caspase-3
| PARP-1
|
Chonglou Saponin VIISupplier
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- 0871-65217109 13211707573;
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- +86-028-82633397 18982077548
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Chonglou Saponin VII(68124-04-9)Related Product Information
- Chonglou Saponin II
- PolyphyllinH
- (25R)-3β-(2-O-α-L-Rhamnopyranosyl-β-D-glucopyranosyloxy)spirosta-5-ene
- ANTI-GALECTIN-7
- Dioscin
- POLYPHYLLIN B (RG)
- Pennogenin3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside
- ALLEOSIDE A
- (3beta,25R)-14-Hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-xylopyranosyl-(1-4)]-beta-D-glucopyranoside
- POLYPHYLLIN D
- 22,25-Epoxy-2,3,14,20-tetrahydroxycholest-7-en-6-one
- Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.
- Bufalin
- Bufotaline
- Polyphyllin VI
- Resibufogenin
- Polyphyllin VII
- beta-Sitosterol