Eriocalyxin B Chemical Properties

Boiling point:

551.1±50.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

pka

11.05±0.60(Predicted)

form 

Solid

color 

White to off-white

InChIKey

RTIKCEKESDRWAE-HCLRZYKANA-N

SMILES

O[C@@]12OC[C@]3(C(C=CC(C)(C)[C@@]3([H])[C@@H]1O)=O)[C@]1([H])CC[C@@]3([H])C(=C)C(=O)[C@@]21C3 |&1:1,4,11,13,16,20,26,r|

Eriocalyxin B Usage And Synthesis

Uses

Eriocalyxin B is an ent-Kaurene diterpenoid isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B has anti-cancer and anti-infammatory activities. Eriocalyxin B induces cell apoptosis[1].

References

[1] Rong-Fang Mu, et al. Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest. Nat Prod Bioprospect. 2020 Jun;10(3):131-140. DOI:10.1007/s13659-020-00240-6
[2] Wang WG, et al. Laxiflorolides A and B, epimeric bishomoditerpene lactones from Isodon eriocalyx. J Nat Prod. 2012 Jun 22;75(6):1102-7.
[3] Zhou X, et al. Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. Biochem Pharmacol. 2017 Oct 15;142:58-70.
[4] Lu Y, et al. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2258-63.
[5] Leung CH, et al. Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner. Mol Pharmacol. 2006 Dec;70(6):1946-55.Leung CH, Grill SP, Lam W, Gao W, Sun HD, Cheng YC. Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner. Mol Pharmacol. 2006 Dec;70(6):1946-55.

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