2,4-Dimethylbromobenzene Chemical Properties

Melting point:

-17°C

Boiling point:

214 °C(lit.)

Density 

1.37 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.551(lit.)

Flash point:

174 °F

storage temp. 

Sealed in dry,Room Temperature

Water Solubility 

Insoluble in water

form 

Liquid

color 

Clear colorless

CAS DataBase Reference

583-70-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-bromo-2,4-dimethyl-(583-70-0)

EPA Substance Registry System

4-Bromo-m-xylene (583-70-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29039990

MSDS

• Language:English Provider:4-Bromo-1,3-dimethylbenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,4-Dimethylbromobenzene Usage And Synthesis

Chemical Properties

Clear colourless to light yellow liquid

Uses

4-Bromo-m-xylene is synthesized by the bromination of alkylbenzene substrates by N-bromosuccinimide.

General Description

Gold-catalyzed coupling reaction of pyrazine with 1-bromo-2,4-dimethylbenzene has been reported. 1-Bromo-2,4-dimethylbenzene reacts with Mg and DMF, followed by the reaction with I₂ and aq.NH₃ to afford the corresponding aromatic nitrile.

Synthesis

General procedure for the synthesis of 2,4-dimethylbromobenzene from m-xylene: N-bromosuccinimide (NBS, 1.0 mmol) and Catalyst 1 (gold loading of 0.1 or 1 mol% of the substrate) were accurately weighed and added to a 10 mL sealed reaction vessel, followed by 1,2-dichloroethane (DCE, 2 mL) and m-xylene (1.0 mmol). The reaction mixture was stirred at a set temperature for a specified time. After completion of the reaction, the catalyst was separated using a magnet and the reaction solution was concentrated under reduced pressure and purified by column chromatography.

References

[1] Russian Journal of Applied Chemistry, 2006, vol. 79, # 6, p. 949 - 956
[2] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447
[3] Tetrahedron Letters, 2013, vol. 54, # 9, p. 1063 - 1066
[4] Russian Journal of Organic Chemistry, 2005, vol. 41, # 11, p. 1631 - 1636
[5] Catalysis Letters, 2012, vol. 142, # 3, p. 378 - 383

2,4-Dimethylbromobenzene(583-70-0)Related Product Information

• 2-Bromofluorobenzene
• 4-Bromobenzaldehyde
• 4'-Bromopropiophenone
• Bromoxynil
• 3-Methylbenzyl bromide
• Xylene
• Bromoxynil octanoate
• 3-Bromoanisole
• Musk xylene
• 2,4,6-Trimethybromombenzene
• 1-BROMO-2,4,6-TRIISOPROPYLBENZENE
• 4-Bromo-3-methylbenzoic acid
• 4-BROMO-3-METHYLBENZONITRILE
• 3-Bromo-2,4,6-trimethylaniline
• 4-Bromo-1,3-bis(trifluoromethyl)benzene
• 2-BROMO-4-NITRO-1,3,5-TRIMETHYLBENZENE
• 3-Aminopyridine
• Bromine