Betamethasone 21-phosphate disodium Chemical Properties

Melting point:

206-211°C

alpha 

+98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)

storage temp. 

room temp

solubility 

Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

form 

Solid

color 

White to Off-White

PH

7.5～9.0(5g/l, 25℃)

Merck 

14,1180

Stability:

Hygroscopic

InChIKey

PLCQGRYPOISRTQ-LWCNAHDDSA-L

SMILES

[C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r|

EPA Substance Registry System

.beta.-Methasone disodium phosphate (151-73-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

TU4056500

HS Code 

29372290

Toxicity

LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90

MSDS

• Language:English Provider:SigmaAldrich

Betamethasone 21-phosphate disodium Usage And Synthesis

Indications and Usage

Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.

Mechanisms of Action

Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.

Contraindications

Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.

Category

Toxic

Toxicity level

Medium

Acute toxicity

Oral administration - mice LD50: >4500 mg/kg

Flammability

Flammable; produces toxic fluoride fumes

Storage and transport

Store in a cool, ventilated, and dry place

Extinguishing agents

Dry powder, foam, sand, carbon dioxide, mist

Chemical Properties

White or almost white powder, very hygroscopic.

Uses

Nasal, Ophthalmic, Oral, Parenteral

Uses

Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.

Definition

ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

brand name

Celestone (Schering).

Biochem/physiol Actions

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

Safety Profile

Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.

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