Basic information Indications and Usage Mechanisms of Action Contraindications Category Toxicity level Acute toxicity Flammability Storage and transport Extinguishing agents Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Hormones and the Endocrine System >  Adrenal corticosteroids >  Betamethasone 21-phosphate disodium

Betamethasone 21-phosphate disodium

Basic information Indications and Usage Mechanisms of Action Contraindications Category Toxicity level Acute toxicity Flammability Storage and transport Extinguishing agents Safety Supplier Related

Betamethasone 21-phosphate disodium Basic information

Product Name:
Betamethasone 21-phosphate disodium
Synonyms:
  • 9a-fluoro-16b-methylprednisolone-21-(disodium phosphate)
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT
  • Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,DisodiumSalt,(11Beta,16Beta)-
  • BETAMETHASONE 21-PHOSPHATE DISODIUM SALT
  • BETAMETHASONESODIUMPHOSPHATE,USP
  • Celestan
  • Disodium betamethasone 21-phosphate
  • Durabetason
CAS:
151-73-5
MF:
C22H28FNa2O8P
MW:
516.4
EINECS:
205-797-0
Product Categories:
  • CELESTONE
  • Intermediates & Fine Chemicals
  • Betamethasone
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
  • Steroids
  • Hormones
  • Steroid Hormones
Mol File:
151-73-5.mol
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Betamethasone 21-phosphate disodium Chemical Properties

alpha 
+98.0~+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
storage temp. 
room temp
storage temp. 
2-8°C
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form 
neat
PH
7.5~9.0(5g/l, 25℃)
Merck 
14,1180
InChIKey
PLCQGRYPOISRTQ-LWCNAHDDSA-L
EPA Substance Registry System
.beta.-Methasone disodium phosphate (151-73-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
TU4056500
HS Code 
29372290
Toxicity
LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90

MSDS

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Betamethasone 21-phosphate disodium Usage And Synthesis

Indications and Usage

Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.

Mechanisms of Action

Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.

Contraindications

Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.

Category

Toxic

Toxicity level

Medium

Acute toxicity

Oral administration - mice LD50: >4500 mg/kg

Flammability

Flammable; produces toxic fluoride fumes

Storage and transport

Store in a cool, ventilated, and dry place

Extinguishing agents

Dry powder, foam, sand, carbon dioxide, mist

Chemical Properties

White or almost white powder, very hygroscopic.

Uses

An anti-inflammatory agent

Uses

A Betamethasone

Uses

antiinflammatory, glucocorticoid

Uses

Nasal, Ophthalmic, Oral, Parenteral

Definition

ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

brand name

Celestone (Schering).

Safety Profile

Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.

Betamethasone 21-phosphate disodiumSupplier

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