5-Chloro-3-(trifluoromethyl)-2-pyridinamine Chemical Properties

Boiling point:

218℃

Density 

1.507

Flash point:

85℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

1.95±0.49(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HS Code 

2933399990

5-Chloro-3-(trifluoromethyl)-2-pyridinamine Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-chloro-3-(trifluoromethyl)pyridin-2-amines from 2-amino-3-trifluoromethylpyridine: Step A Synthesis of 5-chloro-3-(trifluoromethyl)-2-pyridinamine [0120] To a solution of N,N-dimethylformamide (100 mL) containing 3-(trifluoromethyl)-2-pyridinamine (12.2 g, 75 mmol), N-chlorosuccinimide (10.5 g, 79 mmol) was added. The reaction mixture was heated to 60 °C and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated. The residue was purified by silica gel column chromatography using dichloromethane as eluent to give 5-chloro-3-(trifluoromethyl)pyridin-2-amine (13.0 g, 88% yield). m/z 197 (M + 1) by LCMS.

References

[1] Patent: WO2010/91411, 2010, A1. Location in patent: Page/Page column 88-89
[2] Patent: WO2011/41713, 2011, A2. Location in patent: Page/Page column 206
[3] Patent: WO2015/79224, 2015, A1. Location in patent: Page/Page column 60; 61

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