Boc-9-AMino-4,7-Dioxanonanoic acid
Boc-9-AMino-4,7-Dioxanonanoic acid Basic information
- Product Name:
- Boc-9-AMino-4,7-Dioxanonanoic acid
- Synonyms:
-
- Boc-9-AMino-4,7-Dioxanonanoic acid
- Boc-NH-PEG3-CH2CH2COOH
- T-BOC-NH-AMIDO-PEG3-COOH
- t-Boc-N-amido-PEG3-acid
- Boc-PEG3- CH2 CH2COOH
- 5,8,11-Trioxa-2-azatetradecanedioic acid 1-(1,1-dimethylethyl) ester
- Boc-N-amido-PEG3-acid
- t-boc-N-amido-PEG3-propionic acid
- CAS:
- 1347750-75-7
- MF:
- C14H27NO7
- MW:
- 321.37
- Product Categories:
-
- PEGylated Amino Acid
- peg
- Mol File:
- 1347750-75-7.mol
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Boc-9-AMino-4,7-Dioxanonanoic acid Chemical Properties
- Boiling point:
- 471.1±40.0 °C(Predicted)
- Density
- 1.124±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Sparingly), Methanol(Sparingly)
- pka
- 4.28±0.10(Predicted)
- form
- Oil
- color
- Colourless
- InChI
- InChI=1S/C14H27NO7/c1-14(2,3)22-13(18)15-5-7-20-9-11-21-10-8-19-6-4-12(16)17/h4-11H2,1-3H3,(H,15,18)(H,16,17)
- InChIKey
- PFAQEUVPPBOTTA-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCOCCOCCOCCC(O)=O
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Boc-9-AMino-4,7-Dioxanonanoic acid Usage And Synthesis
Description
t-Boc-N-amido-PEG3-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Boc-9-AMino-4,7-Dioxanonanoic acidSupplier
Jiangsu aikang biomedical research and development co., LTD Gold
- Tel
- 025-58859352 13155353615
- qzhang@aikonchem.com
PharmaBlock Sciences (Nanjing),Inc.
- Tel
- 025-86918202 4000255188
- sales@pharmablock.com
Beijing HwrkChemical Technology Co., Ltd
- Tel
- 18515581800 18501085097
- sales.bj@hwrkchemical.com
Accela ChemBio Co.,Ltd.
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
ChemPep, Inc.
- Tel
- +1 (888) 615-9178 / (561) 791-8787
- service@chempep.com
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Boc-9-AMino-4,7-Dioxanonanoic acid(1347750-75-7)Related Product Information
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