3,6,9,12,15,21,24,27,30-Decaoxadotriacontane-1,32-diaMine Chemical Properties

Boiling point:

560.0±45.0 °C(Predicted)

Density 

1.082±0.06 g/cm3(Predicted)

pka

9.04±0.10(Predicted)

form 

Solid-Liquid Mixture

color 

Colorless to off-white

3,6,9,12,15,21,24,27,30-Decaoxadotriacontane-1,32-diaMine Usage And Synthesis

Description

Amino-PEG10-Amine is a crosslinking reagent with two amino groups on both sides. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

IC 50

PEGs

References

[1] Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15. DOI:10.1021/cb3006243

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