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SANTALOL

Basic information Safety Supplier Related

SANTALOL Basic information

Product Name:
SANTALOL
Synonyms:
  • SANTALOL
  • 2-PENTEN-1-OL, 5-(2,3-DIMETHYL TRICYCLO [2.2.1.0(2,6)] HEPT-3-YL)-2-METHYL
  • A AND B-SANTALOL
  • SANTALOL ALPHA- AND BETA- FCC
  • D-ALPHA-SANTALOL
  • CIS-ALPHA-SANTALOL
  • FEMA 3006
  • 2-Methyl-5-((1S,2S,4R)-2-Methyl-3-Methylenebicyclo[2.2.1]heptan-2-yl)pent-2-en-1-ol
CAS:
11031-45-1
MF:
C15H24O
MW:
220.35
EINECS:
234-262-4
Mol File:
11031-45-1.mol
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SANTALOL Chemical Properties

Density 
0.968 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.507(lit.)
FEMA 
3006 | SANTALOL (ALPHA AND BETA )
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
color 
Colourless
Odor
at 100.00 %. deep sweet sandalwood woody
Odor Type
woody
JECFA Number
984
Boiling point:
101-103°C/0.1 mmHg(lit.)
InChI
InChI=1S/C15H24O/c1-11(10-16)5-4-8-15(3)12(2)13-6-7-14(15)9-13/h5,13-14,16H,2,4,6-10H2,1,3H3/b11-5+
InChIKey
OJYKYCDSGQGTRJ-VZUCSPMQSA-N
SMILES
C1(C)(CC/C=C(\C)/CO)C(=C)C2CCC1C2
LogP
4.65
EPA Substance Registry System
Santalol (11031-45-1)
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SANTALOL Usage And Synthesis

Chemical Properties

Santalol (α- and β-) has a sweet, sandalwood odor.

Occurrence

The stereochemistry of santalols has been discussed by Brieger (Burdock, 1995); santalols are found among the constituents of various sandalwood species (Santalum album L., S. spicatum, S. autrocaledonicum); the α- and β-isomers are present in varying ratios, with the α-isomer usually more abundant.

Uses

Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects with a sweet woody odor making it useful in essential oils.

Uses

Santalol, α- and β-isomers are used as analytical standards for the quantification of the analytes in fragrances using flow-modulation comprehensive two-dimensional gas chromatography coupled to mass spectrometry (FM GCxGC/MS).

Uses

Santalol is a flavoring agent that is a colorless or pale yellow liquid, with odor resembling sandalwood. it is soluble in alcohol, fixed oils, mineral oil, and propylene glycol; and insoluble in water and glyc- erin. it is obtained from a sandalwood oil source.

Synthesis

The commercial product is generally a mixture of α- and β-santalol obtained by fractional distillation of sandalwood oil; noncommercial syntheses are known.

in vivo

α-Santalol (i.p. 12.5 mg/kg, 25 mg/kg, 50 mg/kg) prolongs the sleeping time more than β-Santalol when they were each administered intragastrically in male ddY mice[3].
α-Santalol (i.p. 12.5 mg/kg, 25 mg/kg, 50 mg/kg) reduces rectal temperature in a dose-related manner following i.p. administration and the magnitude of activity is greater than that of β-Santalol in male ddY mice [3].
α-Santalol and β-Santalol (p.o., 50 mg/kg, 100 mg/kg, 200 mg/kg) shows significant antinociceptive activities in male ddY mice[3].
α-Santalol and β-Santalol (i.p., 50 mg/kg) decreases spontaneous activity and simultaneously shows motor incoordination, such as catalepsy, but does not cause ptosis, hypnosis and muscle relaxation in male ddY mice [3].
α-Santalol (i.p., 25 mg/kg, 50 mg/kg) causes a greater reduction in methamphetamine-induced (at 2 mg/kg) motilities than β-Santalol in male ddY mice [3].
α-Santalol and β-Santalol (i.p., 25 mg/kg, 50 mg/kg) significantly decreases apomorphine-induced (2 mg/kg) movements in male ddY mice [3].
α-Santalol (i.p., 50 mg/kg) significantly increases the levels of HVA (homovanillic acid), and 5-HIAA (5-hydroxyindoleacetic acid) in the brain of treated mice[3].
β-Santalol (i.p., 50 mg/kg) increases the levels of DOPAC (3,4-dihydroxyphenylacetic acid), and 5-HT(serotonin creatinine sulfate) besides HVA and 5-HIAA in male ddY mice[3].

SANTALOL Preparation Products And Raw materials

Raw materials

XyleneFEMA 3005

SANTALOLSupplier

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