5,7-Dichloropyrido[4,3-b]pyrazine Chemical Properties

Boiling point:

350.8±37.0 °C(Predicted)

Density 

1.573±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-0.71±0.30(Predicted)

Appearance

yellow solid

InChI

InChI=1S/C7H3Cl2N3/c8-5-3-4-6(7(9)12-5)11-2-1-10-4/h1-3H

InChIKey

SNWNPXRUXXCDOM-UHFFFAOYSA-N

SMILES

C12=C(Cl)N=C(Cl)C=C1N=CC=N2

5,7-Dichloropyrido[4,3-b]pyrazine Usage And Synthesis

Synthesis

2,6-Dichloro-3,4-pyridinediamine (7.85 g, 0.044 mol) and 40% aqueous glyoxal (26 g, 0.178 mol) were mixed in ethanol and the reaction was carried out at reflux overnight. After completion of the reaction, the mixture was cooled to room temperature, the precipitate was collected, washed with ethanol and dried under vacuum to give 5,7-dichloropyrido[3,4-b]pyrazine (7.32 g, 83% yield).

References

[1] Patent: WO2012/167733, 2012, A1. Location in patent: Page/Page column 35
[2] Patent: WO2012/167423, 2012, A1. Location in patent: Page/Page column 32
[3] Patent: US2014/121200, 2014, A1. Location in patent: Paragraph 0143; 0147
[4] Patent: WO2012/123312, 2012, A1. Location in patent: Page/Page column 63
[5] Patent: US2014/5188, 2014, A1. Location in patent: Paragraph 0562; 0563; 0564

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