WAY-600
WAY-600 Basic information
- Product Name:
- WAY-600
- Synonyms:
-
- WAY-600
- 6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
- 6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine
- WAY-600;WAY 600
- 4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine
- 1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-
- WAY-600 USP/EP/BP
- CAS:
- 1062159-35-6
- MF:
- C28H30N8O
- MW:
- 494.59
- Product Categories:
-
- Inhibitors
- Akt
- PI3K/Akt/mTOR
- mTOR
- PI3K
- Mol File:
- 1062159-35-6.mol
WAY-600 Chemical Properties
- Density
- 1.43
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 16.08±0.30(Predicted)
WAY-600 Usage And Synthesis
Biological Activity
WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with IC50 of 9 nM for recombinant mTOR enzyme. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.
in vitro
WAY-600 decreased exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically . Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. It dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association ) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).
in vivo
Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, po daily).
target
| mTOR 9 nM (IC 50 ) | mTORC1 < /span> | mTORC2
| PI3K alpha 1.96 μM (IC 50 ) | PI3K gamma 8.45 μM (IC 50 ) |
WAY-600Supplier
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Tel
- 18521735133 18521732826;
- market@aladdin-e.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- +1 (866) 930-6790
- info@adooq.com
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