Scabertopin Chemical Properties

Boiling point:

592.7±50.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

form 

Solid

color 

White to light yellow

InChI

InChI=1S/C20H22O6/c1-5-11(3)18(21)25-16-9-13-8-14(24-20(13)23)6-10(2)7-15-17(16)12(4)19(22)26-15/h5,7-8,14-17H,4,6,9H2,1-3H3/b10-7+,11-5-/t14-,15+,16-,17-/m0/s1

InChIKey

FTPHYXGWMIZVMP-RZYABJHASA-N

SMILES

C(O[C@H]1CC2=C[C@]([H])(CC(C)=C[C@@]3([H])OC(=O)C(=C)[C@@]31[H])OC2=O)(=O)/C(/C)=C\C |t:10|

Scabertopin Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Elephantopus scaber.

Uses

Scabertopin is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents[1][2].

Health effects

Didancao species lactone has anti-tumor effect: Didancao has inhibitory effect on the proliferation of various tumor cells.

Biological Activity

Scabertopin, isolated from Elephantopus scaber, is a sesquiterpene lactone. It is an important anticancer ingredient.

References

[1] Liang QL, et al. [Structure modification on sesquiterpene lactones from Elephantopus scaber]. Yao Xue Xue Bao. 2007 Nov;42(11):1159-61. PMID:18300472
[2] Hiradeve SM, et al. A review on pharmacology and toxicology of Elephantopus scaber Linn. Nat Prod Res. 2014;28(11):819-30. DOI:10.1080/14786419.2014.883394

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