1,3-Dichloro-4-fluorobenzene Chemical Properties

Melting point:

-23 °C

Boiling point:

172-174 °C(lit.)

Density 

1.409 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.525(lit.)

Flash point:

98 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

1.409

Water Solubility 

insoluble

BRN 

2500791

InChI

InChI=1S/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H

InChIKey

BDJZCCWUSOZUQG-UHFFFAOYSA-N

SMILES

C1(F)=CC=C(Cl)C=C1Cl

CAS DataBase Reference

1435-48-9(CAS DataBase Reference)

NIST Chemistry Reference

1,3-Dichloro-4-fluorobenzene(1435-48-9)

Safety Information

Hazard Codes 

Xn,N,Xi

Risk Statements 

22-38-48/20/22-51/53-10-36/37/38

Safety Statements 

36/37-61-16-36-26

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

9

PackingGroup 

III

HS Code 

29039990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,3-Dichloro-4-fluorobenzene Usage And Synthesis

Chemical Properties

Clear colourless to yellow liquid

Uses

1, 3-dichloro-4-fluorobenzene is a multifunctional chemical reagent. Its benzene ring structure formula contains fluorine and chlorine functional groups and can be used in various reaction systems. It is widely applied in the field of organic synthesis.

Synthesis

The general procedure for the synthesis of 2,4-dichlorofluorobenzene from 3-chloro-4-fluoronitrobenzene is as follows: 240 g (1.37 mol) of 3-chloro-4-fluoronitrobenzene was added to a 250 ml four-necked flask and the temperature of the reaction system was raised to 170°C. The temperature of the reaction system was raised to 170°C. The reaction system was then purged with dry chlorine. Dry chlorine gas was slowly passed in the temperature range of 170 to 180 °C. The reaction process was carried out by distillation for 8 hours and the distillate was collected. The distillate was subsequently washed with water and then with alkali to a weakly basic pH. The organic phase was separated and purified by distillation, resulting in 207 g of 2,4-dichlorofluorobenzene with 99.8% purity and 91.7% yield.

References

[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0020; 0075-0076
[2] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 98,109

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