N-(4-BroMophenyl)-N,N-bis(1,1'-biphenyl-4-yl)aMine Chemical Properties

Melting point:

172-174℃

Boiling point:

625.7±55.0 °C(Predicted)

Density 

1.296

storage temp. 

Sealed in dry,Room Temperature

solubility 

slightly sol. in Tetrahydrofuran

form 

powder to crystal

pka

-3.76±0.50(Predicted)

color 

White to Almost white

Safety Information

HS Code 

2921490090

N-(4-BroMophenyl)-N,N-bis(1,1'-biphenyl-4-yl)aMine Usage And Synthesis

Synthesis

The general procedure for the synthesis of N-(4-bromophenyl)-N,N-bis(1,1'-biphenyl-4-yl)amine from p-bromoiodobenzene and bis(4-biphenyl)amine was as follows: bis(4-biphenyl)amine (23.7 g, 73.8 mmol) was added to a round-bottomed flask, followed by the addition of p-bromoiodobenzene (20.9 g, 73.8 mmol), sodium tert-butanolate (10.7 g, 111 mmol), p-butylpropanol (0.33 g, 1.47 mmol), and ultrasonically deoxygenated toluene (1.5 L). 111 mmol), palladium acetate (0.33 g, 1.47 mmol), and ultrasonically deoxygenated toluene (1.5 L). The mixture was heated to reflux overnight under nitrogen protection. After completion of the reaction, the reaction solution was cooled and extracted with ethyl acetate and water. The organic layer was separated and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by column chromatography using silica gel as stationary phase and dichloromethane/hexane as eluent to afford the target product N-(4-bromophenyl)-N,N-bis(1,1'-biphenyl-4-yl)amine (28.8 g, 82% yield).

References

[1] Patent: CN107652189, 2018, A. Location in patent: Paragraph 0068; 0069-0071
[2] Patent: CN107739377, 2018, A. Location in patent: Paragraph 0075-0078
[3] Patent: CN107986975, 2018, A. Location in patent: Paragraph 0074-0075
[4] Patent: CN108148016, 2018, A. Location in patent: Paragraph 0082; 0083; 0084
[5] Patent: EP2292603, 2011, A1. Location in patent: Page/Page column 25

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