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NVP-BGJ398

Basic information Uses Safety Supplier Related

NVP-BGJ398 Basic information

Product Name:
NVP-BGJ398
Synonyms:
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
  • BGJ 398
  • BGJ-398
  • BGJ398 (NVP-BGJ398)
  • NVP-BGJ398
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea NVP-BGJ398
  • NVP-BGJ398 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
  • Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, methanesulfonate
CAS:
872511-34-7
MF:
C26H31Cl2N7O3
MW:
560.48
Product Categories:
  • Inhibitors
  • Inhibitor
  • API
Mol File:
872511-34-7.mol
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NVP-BGJ398 Chemical Properties

Melting point:
>211°C (dec.)
Boiling point:
747.9±60.0 °C(Predicted)
Density 
1.354
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 5 mg/ml)
form 
White solid.
pka
11.02±0.70(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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NVP-BGJ398 Usage And Synthesis

Uses

BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Description

NVP-BGJ398 (872511-34-7) is a potent and selective pan-FGFR inhibitor (IC50?= 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1? It has also been used in a mouse model of Achondroplasia (most common form of dwarfism) to correct pathological hallmarks of this condition.

Uses

BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

References

1) Guagnano?et al.?(2011),?Discovery of 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea (NVP-BGJ398),?a Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase?; J. Med. Chem.?54?7066 2) Komla-Ebri?et al.?(2016),?Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model; J. Clin. Invest.?126?1871

NVP-BGJ398Supplier

YouCoChem (Beijing) Chemical Technology Co., Ltd. Gold
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