GW 627368X Chemical Properties

Density 

1.327±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

form 

Powder

pka

5.25±0.10(Predicted)

GW 627368X Usage And Synthesis

Description

The effects of prostaglandin E₂ (PGE₂) are transduced by at least four distinct receptors designated EP₁, EP₂, EP₃, and EP₄. GW 627368X is a potent and selective competitive antagonist of the EP₄ receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP₄ and TP receptors with K_i values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 μM. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 μM.

Uses

GW 627368 is a selective EP4 receptor competitive antagonist.

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