Basic information Reaction Safety Supplier Related

BrettPhosPalladacycle

Basic information Reaction Safety Supplier Related

BrettPhosPalladacycle Basic information

Product Name:
BrettPhosPalladacycle
Synonyms:
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II),98%
  • BrettPhos Pd G1 Methyl-t-Butyl Ether Adduct
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II), Min. 98% [BrettPhos Palladacycle]
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoeth
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-Minoethyl)phenyl]palladiuM(II),Min.98%[BrettPhosPalladacycle]
  • (BrettPhos) palladium(II) phenethylamine chloride
  • BrettPhos Palladacycle
CAS:
1148148-01-9
MF:
C43H63ClNO2PPd
MW:
798.83
Product Categories:
  • Buchwald Ligands&Precatalysts
  • Buchwald Precatalysts Series
  • Pd
Mol File:
1148148-01-9.mol
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BrettPhosPalladacycle Chemical Properties

Melting point:
198-204 °C
form 
Powder
color 
white
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
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BrettPhosPalladacycle Usage And Synthesis

Reaction

  1. Catalyst for cross-coupling reactions using aryl mesylates with electron-deficient anilines.
  2. Catalyst for rapid C-N bond-forming processes at low catalyst loading.
  3. Cross-coupling of 3-Bromo-2-aminopyridine with primary amines.

Uses

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst for:

  • C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
  • Amination reaction
  • N-arylation of aminophenols

General Description

BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to ?40 °C, and can be used in a variety of cross-coupling protocols.

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