Quinuclidine-4-carboxylic acid hydrochloride Chemical Properties

Melting point:

>360 °C(Solv: ethanol (64-17-5))

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to light yellow Solid

InChI

InChI=1S/C8H13NO2.ClH/c10-7(11)8-1-4-9(5-2-8)6-3-8;/h1-6H2,(H,10,11);1H

InChIKey

JTYXRFSULOZNPH-UHFFFAOYSA-N

SMILES

N12CCC(C(O)=O)(CC1)CC2.[H]Cl

Quinuclidine-4-carboxylic acid hydrochloride Usage And Synthesis

Uses

4-Quinuclidinecarboxylic Acid Hydrochloride is a useful research chemical compound used in the of pleuromutilin derivatives as antimicrobials.

Synthesis

General procedure for the synthesis of 1-azabicyclo[2.2.2]octane-4-carboxylic acid hydrochloride from 4-cyanoquinuclidine: Quinuclidine-4-carbonitrile (4 g, 29.4 mmol) was dissolved in 30 mL of aqueous 6N hydrochloric acid and the reaction was stirred under refluxing conditions for 16 hours. Upon completion of the reaction, the reaction mixture was cooled and subsequently evaporated to dryness under reduced pressure. The resulting solid was ground with 20% ether-hexane mixture to give the final quinuclidine-4-carboxylic acid hydrochloride (5.5 g, quantitative yield).

References

[1] Patent: US2016/9706, 2016, A1. Location in patent: Paragraph 0193

Quinuclidine-4-carboxylic acid hydrochloride(40117-63-3)Related Product Information

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