Oxamic acid sodium salt Chemical Properties

Melting point:

300 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

PBS (pH 7.2): 10 mg/ml

form 

solid

Water Solubility 

Soluble in water (10 mg/ml).

BRN 

6538153

InChI

InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1

InChIKey

RQVZIJIQDCGIKI-UHFFFAOYSA-M

SMILES

C(=O)(N)C([O-])=O.[Na+]

CAS DataBase Reference

565-73-1(CAS DataBase Reference)

EPA Substance Registry System

Sodium oxamate (565-73-1)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

10

TSCA 

Yes

HS Code 

29241990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Oxamic acid sodium salt Usage And Synthesis

Description

Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.

Chemical Properties

white crystalline powder

Uses

Oxamic acid sodium salt is a lactate dehydrogenase (LDH) inhibitor. It is a suitable compound to investigate cancer cells that utilize the glycolytic pathway.This compound is suitable for lactate dehydrogenase (LDH) related research. It can be used as an inhibitor of gluconeogenesis useful for anticancer research.

Application

Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.

Biochem/physiol Actions

Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.

in vitro

Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells.

Oxamic acid sodium salt(565-73-1)Related Product Information

• Sodium phytate
• ETHYL OXAMATE
• Ferric ammonium oxalate trihydrate
• Stannous oxalate
• POTASSIUM TITANIUM OXALATE DIHYDRATE
• Ferrous oxalate dihydrate
• Potassium binoxalate
• EC 2.7.1.40
• Oxalic acid
• Oxamic acid
• SODIUM GLYOXYLATE
• Oxamic acid sodium salt