Basic information Safety Supplier Related

Boc-NH-PEG(3)-COOH

Basic information Safety Supplier Related

Boc-NH-PEG(3)-COOH Basic information

Product Name:
Boc-NH-PEG(3)-COOH
Synonyms:
  • Boc-NH-PEG(3)-COOH
  • Boc-NH-PEG(3)-COOH(16atoMs)
  • Boc-NH-(PEG)4-CH2COOH
  • t-Boc-N-amido-PEG4-CH2CO2H
  • 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid
  • 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid, 1-(1,1-dimethylethyl) ester
  • 14-(Boc-amino)-3,6,9,12-tetraoxatetradecan-1-oic Acid
  • t-boc-N-amido-PEG4-acetic acid
CAS:
876345-13-0
MF:
C15H29NO8
MW:
351.39
Mol File:
876345-13-0.mol
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Boc-NH-PEG(3)-COOH Chemical Properties

Boiling point:
493.6±40.0 °C(Predicted)
Density 
1.138±0.06 g/cm3(Predicted)
storage temp. 
-20°C
pka
3.39±0.10(Predicted)
form 
Viscous Liquid
color 
Colorless to light yellow
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Boc-NH-PEG(3)-COOH Usage And Synthesis

Description

t-Boc-N-amido-PEG4-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation

Boc-NH-PEG(3)-COOHSupplier

Xi‘an Deeptech Biotechnology Co.,LTD Gold
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+86-15114901355 +86-15114901355
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Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd Gold
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Energy Chemical
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Accela ChemBio Co.,Ltd.
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Chengdu Pukang Biotechnology Co., Ltd
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028-82550498 19102685862
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sales@pu-kang.com