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(+/-)-THIOPENTAL

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(+/-)-THIOPENTAL Basic information

Product Name:
(+/-)-THIOPENTAL
Synonyms:
  • 5-ETHYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID
  • 5-ETHYL-5-PENTAN-2-YL-2-SULFANYL-1H-PYRIMIDINE-4,6-DIONE
  • 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione
  • (±)thiopental solution
  • 2-Thio-5-ethyl-5-sec-pentylbarbituric acid
  • 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (9CI)
  • Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio- (8CI)
  • PENTOTHAL ACID
CAS:
76-75-5
MF:
C11H18N2O2S
MW:
242.34
EINECS:
200-984-3
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
76-75-5.mol
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(+/-)-THIOPENTAL Chemical Properties

Melting point:
158-160°C
Density 
1.1789 (rough estimate)
refractive index 
1.5440 (estimate)
Flash point:
11℃
storage temp. 
2-8°C
solubility 
ethanol: complete50mg/mL
pka
7.11±0.40(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
50mg/L(25 ºC)
CAS DataBase Reference
76-75-5(CAS DataBase Reference)
EPA Substance Registry System
4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (76-75-5)
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
36/37/39-45-36/37-16-7
RIDADR 
UN 1230 3/PG 2
WGK Germany 
3
RTECS 
CQ6300000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933595960
Hazardous Substances Data
76-75-5(Hazardous Substances Data)
Toxicity
cyt-hmn:leu 1500 mg/L TGANAK18(1),13,84

MSDS

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(+/-)-THIOPENTAL Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Pentothal,Abbott

Uses

A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic

Definition

ChEBI: Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It is functionally related to a 2-thiobarbituric acid. It is a conjugate acid of a thiopental(1-).

Manufacturing Process

130 g of ethyl (1-methylbutyl) malonic ester is added to a concentrated solution of sodium ethylate prepared from 34 g of sodium in absolute alcohol; with stirring, 60 g of finely divided thiourea is added, and, the mixture refluxed for 10 hours. Most or all of the solvent is evaporated and the residual mass is dissolved in cold water. The barbituric acid derivative so formed is precipitated by the addition of dilute hydrochloric acid. It may be 1 purified by solution in dilute ammonium hydroxide solution and precipitated by carbon dioxide, followed by recrystallization from 95% alcohol. The ethyl (1- methylbutyl)thiobarbituric acid so obtained is a white crystalline solid, melting at 158-159°C and readily forming salts with alkalies.

brand name

Thiopental is BAN.

Therapeutic Function

Narcotic analgesic, Anesthetic

Safety Profile

Poison by intraperitoneal, intravenous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Human mutation data reported. A short-acting intravenous anesthetic. When heated to decomposition it emits very toxic fumes of NOx and SOx

(+/-)-THIOPENTALSupplier

Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com
Chizhou Kailong Import and Export Trade Co., Ltd.
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Email
xg01_gj@163.com
Sigma-Aldrich
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021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Email
wxf@sungening.com
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-88380327 17691182729
Email
1018@dideu.com