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Acethydrazide

Basic information Description Safety Supplier Related

Acethydrazide Basic information

Product Name:
Acethydrazide
Synonyms:
  • 374
  • Acetyl hydrazide
  • ACETIC ACID HYDRAZIDE
  • ACETOHYDRAZIDE
  • ACETIC HYDRAZIDE
  • ACETHYDRAZIDE
  • AKOS 90782
  • Acethydrazide=Acetylhydrazide
CAS:
1068-57-1
MF:
C2H6N2O
MW:
74.08
EINECS:
213-948-7
Product Categories:
  • Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
  • bc0001
  • 1068-57-1
Mol File:
1068-57-1.mol
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Acethydrazide Chemical Properties

Melting point:
58-68 °C (lit.)
Boiling point:
129 °C/18 mmHg (lit.)
Density 
1.0968 (rough estimate)
refractive index 
1.4264 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Moist Crystals and Chunks
pka
13.46±0.18(Predicted)
color 
White
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
506165
InChIKey
OFLXLNCGODUUOT-UHFFFAOYSA-N
CAS DataBase Reference
1068-57-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, hydrazide(1068-57-1)
EPA Substance Registry System
Acetic acid hydrazide (1068-57-1)
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Safety Information

Hazard Codes 
Xn,T
Risk Statements 
22-36/38-68-40-25
Safety Statements 
26-36-45-36/37
RIDADR 
1759
WGK Germany 
1
RTECS 
AI1225000
3-8-10
TSCA 
Y
HazardClass 
6.1
PackingGroup 
II
HS Code 
29280090
Toxicity
LD50 oral in bird - wild: 42200ug/kg

MSDS

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Acethydrazide Usage And Synthesis

Description

Acethydrazide is an essential organic intermediate mainly used to synthesize nifuratrone in the pharmaceutical industry. It belongs to the hydrazine/hydrazone group, which plays an important role in the anti-microbial activity. Recently, Acethydrazide has gained significant importance due to its anti-tuberculosis activity. A disease caused by parasites represents a major world health problem with limited therapeutic options. Acethydrazide was synthesized from the reaction between ethyl acetate and hydrazine hydrate in methanol solvent and purified[1-2].

Chemical Properties

White moist crystals and chunks

Uses

Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.

Uses

Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.

Uses

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

Definition

ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.

Purification Methods

Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]

References

[1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28.
[2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152.

Acethydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

AcethydrazideSupplier

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