Acethydrazide Chemical Properties

Melting point:

58-68 °C (lit.)

Boiling point:

129 °C/18 mmHg (lit.)

Density 

1.0968 (rough estimate)

refractive index 

1.4264 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Moist Crystals and Chunks

pka

13.46±0.18(Predicted)

color 

White

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

506165

InChIKey

OFLXLNCGODUUOT-UHFFFAOYSA-N

CAS DataBase Reference

1068-57-1(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, hydrazide(1068-57-1)

EPA Substance Registry System

Acetic acid hydrazide (1068-57-1)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/38-68-40-25

Safety Statements 

26-36-45-36/37

RIDADR 

1759

WGK Germany 

1

RTECS 

AI1225000

F 

3-8-10

TSCA 

Y

HazardClass 

6.1

PackingGroup 

II

HS Code 

29280090

Toxicity

LD50 oral in bird - wild: 42200ug/kg

MSDS

• Language:English Provider:Acethydrazide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Acethydrazide Usage And Synthesis

Description

Hydrazine, anhydrous appears as a colorless, fuming oily liquid with an ammonia-like odor. Flash point 99°F. Explodes during distillation if traces of air are present. Toxic by inhalation and by skin absorption. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

Chemical Properties

White moist crystals and chunks

Uses

Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.

Uses

Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.

Uses

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

Definition

ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.

Purification Methods

Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]

Acethydrazide(1068-57-1)Related Product Information

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