McMMAE
McMMAE Basic information
- Product Name:
- McMMAE
- Synonyms:
-
- Mc MMAE
- McMMAE
- Mc-MMAE
- 37: PN: WO2007140371 PAGE: 273 claimed sequence
- Maleimidocaproyl-monomethylauristatin E
- L-Valinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
- Mc-MMAE,Inhibitor,Drug-Linker Conjugates for ADC,McMMAE,Microtubule/Tubulin,Mc MMAE,inhibit
- 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-N-methylhexanamide
- CAS:
- 863971-24-8
- MF:
- C49H78N6O10
- MW:
- 911.18
- Product Categories:
-
- ADCs
- ADC LINKER
- Mol File:
- 863971-24-8.mol
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McMMAE Chemical Properties
- Boiling point:
- 1025.2±65.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMSO: ≥ 51 mg/mL (55.97 mM)
- pka
- 13.63±0.46(Predicted)
- form
- Powder
- color
- White to light yellow
- InChIKey
- MMUKUGXLBJUPND-AXJCKIDNSA-N
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McMMAE Usage And Synthesis
Uses
Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a agent-linker conjugate for ADC.
IC 50
Auristatin
References
[1] Sanderson RJ, et al. In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):843-52. PMID:15701875
McMMAESupplier
Shanghai ruichang pharmaceutical technology co., LTD Gold
- Tel
- 18621054990
- maychemicals@sina.com
Chuzhou KeMail Chemical Technology Co., Ltd Gold
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- 0550-5196001 15000891977
- wj520wjxby@126.com
Shanghai Topbiochem Technology Co., Ltd
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- 021-58170097
- info@topbiochem.com
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
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MedChemexpress LLC
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- 021-58955995
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