(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Chemical Properties

Boiling point:

387.9±42.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

pka

6.93±0.60(Predicted)

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Usage And Synthesis

Uses

Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride(1185503-48-3)Related Product Information

• Fosaprepitant Impurity 6
• [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
• (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
• 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
• Aprepitant
• Fosaprepitant Impurity 5
• 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one
• (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one
• 1,1,1-Trimethoxy-2-chloroethane
• Aprepitant
• (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
• Benzyl dihydrogen phosphate
• (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
• Aprepitant
• Aprepitant
• (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine
• (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
• Aprepitant Impurity 17